구강편평세포암종에서의 Ki-67과 p53의 발현 ; 구강내 원발성 편평세포암종과 림프절로 전이된 편평세포암종의 비교
Expression of Ki-67 and p53 in Oral Squamous Cell Carcinoma; Primary OSCC in Oral Cavity vs Metastaic OSCC in Lymph Node
최소영, 김진욱, 박영인, 강성민, 홍수형,
소속 상세정보
최소영 ( Choi So-Young ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
김진욱 ( Kim Jin-Wook ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
박영인 ( Park Young-In ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
강성민 ( Kang Sung-Min ) - 경북대학교 치의학전문대학원 구강미생물학교실
홍수형 ( Hong Su-Hyung ) - 경북대학교 치의학전문대학원 구강미생물학교실
KMID : 0829220160400030801
Abstract
This study was performed to investigate the correlation between the primary squamous cell carcinoma in oral cavity (POSCC) and paired metastatic oral squamous cell carcinoma in cervical lymph node (MOSCC) via immunohistochemical staining with Ki-67 and p53. The subjects included ten patients (20 specimens) who were diagnosed with OSCC with metastatic lymph nodes from 2010 to 2015 and surgically treated involving neck dissection in Kyungpook National University Hospital. Twenty specimens were stained immunohistochemically with Ki-67 and p53. The degrees of immunostaining by Ki-67 and p53 was evaluated as 0 (no positive cells), weak (1~25% positive cells), moderate (26-50% positive cells) and strong (>50% positive cells). Despite the strong tendency, there was no statistically significant result between expressions of Ki-67 and p53 in POSCC or MOSCC. We found that high expression of Ki-67 was significantly correlated with poor degree of differentiation. Our results suggest that expression of Ki-67 may be a predictable factor for degree of differentiation of POSCC and MOSCC.
키워드
Oral squamous cell carcinoma; Ki-67; p53; Immunohistochemistry
원문 및 링크아웃 정보
등재저널 정보